2020
Asquith, C. R. M.; Laitinen, T.; Bennett, J. M.; Wells, C. I.; Elkins, J. M.; Zuercher, W. J.; Tizzard, G. J.; Poso, A., Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem 2020, 15 (1), 26-49.
Asquith, C. R. M.; Laitinen, T.; Wells, C. I.; Tizzard, G. J.; Zuercher, W. J., New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K). Molecules 2020, 25 (7).
Bruch, Q. J.; Miller, A., A bis(arylphosphinito)amide pincer ligand that binds nickel forming six-membered metallacycles. Polyhedron 2020, 179, 114380.
Kessler, M. L.; Dempsey, J. L., Mapping the Topology of PbS Nanocrystals through Displacement Isotherms of Surface-Bound Metal Oleate Complexes. Chemistry of Materials 2020, 32 (6), 2561-2571.
Smith, K. L.; Padgett, C. L.; Mackay, W. D.; Johnson, J. S., Catalytic, Asymmetric Dearomative Synthesis of Complex Cyclohexanes via a Highly Regio- and Stereoselective Arene Cyclopropanation Using α-Cyanodiazoacetates. Journal of the American Chemical Society 2020, 142 (14), 6449-6455.
Zavesky, B. P.; De Jesús Cruz, P.; Johnson, J. S., Progress toward a Convergent, Asymmetric Synthesis of Jervine. Organic Letters 2020.
2019
Asquith, C.; Berger, B.; Wan, J.; Bennett, J.; East, M.; Elkins, J.; Fedorov, O.; Godoi, P.; Hunter, D.; Knapp, S.; Mueller, S.; Wells, C.; H. Earp, S.; Willson, T.; Zuercher, W., SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem 2019, 62 (5), 2830-2836.
Asquith, C.; Bieberich, A.; Maffuid, K.; Fatig, R.; Tizzard, G.; Laitinen, T.; East, M.; Torrice, C.; Drewry, D.; Johnson, G.; Crona, D.; Calvin, B.; Morris, D.; Zuercher, W., Optimization of structural features of the 4-anilinoquin(az)oline scaffold for chordoma utilizing an innovative toxicology profiling assay panel. Abstr Pap Am Chem S 2019, 257.
Asquith, C.; Maffuid, K.; Laitinen, T.; Torrice, C.; Tizzard, G.; Alamillo-Ferrer, C.; Koshlap, K.; Crona, D.; Zuercher, W., Design and evaluation of novel 4-anilinoquinolines and quinazolines as EGFR inhibitors in lung cancer and chordoma. 2019.
Asquith, C. R. M.; Bennett, J. M.; Su, L. Y.; Laitinen, T.; Elkins, J. M.; Pickett, J. E.; Wells, C. I.; Li, Z. B.; Willson, T. M.; Zuercher, W. J., Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK). Molecules 2019, 24 (22).
Asquith, C. R. M.; Fleck, N.; Torrice, C. D.; Crona, D. J.; Grundner, C.; Zuercher, W. J., Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines. Bioorg Med Chem Lett 2019, 29 (18), 2695-2699.
Asquith, C. R. M.; Laitinen, T.; Bennett, J. M.; Wells, C. I.; Elkins, J. M.; Zuercher, W. J.; Tizzard, G. J.; Poso, A., Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships. ChemMedChem 2019.
Asquith, C. R. M.; Maffuid, K. A.; Laitinen, T.; Torrice, C. D.; Tizzard, G. J.; Crona, D. J.; Zuercher, W. J., Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma. ChemMedChem 2019, 14 (19), 1693-1700.
Asquith, C. R. M.; Naegeli, K. M.; East, M. P.; Laitinen, T.; Havener, T. M.; Wells, C. I.; Johnson, G. L.; Drewry, D. H.; Zuercher, W. J.; Morris, D. C., Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma. Journal of Medicinal Chemistry 2019, 62 (9), 4772-4778.
Asquith, C. R. M.; Tizzard, G. J., 6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine. Molbank 2019, 2019, M1087.
Asquith, C. R. M.; Treiber, D. K.; Zuercher, W. J., Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK) Bioorg. Med. Chem. Lett. 2019, 29, 1727-1731.
Ballinger, E.; Mosior, J.; Hartman, T.; Burns-Huang, K.; Gold, B.; Morris, R.; Goullieux, L.; Blanc, I.; Vaubourgeix, J.; Lagrange, S.; Fraisse, L.; Sans, S.; Couturier, C.; Bacqué, E.; Rhee, K.; Scarry, S.; Aube, J.; Yang, G.; Ouerfelli, O.; Schnappinger, D.; Loerger, T.; Engelhart, C.; McConnell, J.; McAulay, K.; Fay, A.; Roubert, C.; Sacchettini, J.; Nathan, C., Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science 2019, 363 (6426).
Bruch, Q. J.; Connor, G. P.; Chen, C.; Holland, P. L.; Mayer, J. M.; Hasanayn, F.; Miller, A., Dinitrogen Reduction to Ammonium at Rhenium Utilizing Light and Proton-Coupled Electron Transfer. Journal of the American Chemical Society 2019, 141 (51), 20198-20208.
Carabajal, M. A.; Asquith, C. R. M.; Laitinen, T.; Tizzard, G. J.; Yim, L.; Rial, A.; Chabalgoity, J. A.; Zuercher, W. J.; Garcia Vescovi, E., Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System. Antimicrob Agents Chemother 2019, 64 (1).
Cesta, D.; Karakaya, S.; Saito, K.; Javidnia, P.; Roberts, J.; Ling, Y.; Gold, B.; Quezada, L.; Zhang, D.; Abramyan, T.; Kireev, D.; Aube, J.; Scarry, S., Synthesis and Antibacterial Evaluation of Cephalosporin Isosteres. Asian Journal of Organic Chemistry 2019.
Ervin, S. M.; Hanley, R. P.; Lim, L.; Walton, W. G.; Pearce, K. H.; Bhatt, A. P.; James, L. I.; Redinbo, M. R., Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial b-Glucuronidases. ACS Chemical Biology 2019.
Goines, S.; Dick, J. E., Electrochemical Characterization of Nicotinamide Riboside. ChemElectroChem 2019, 6 (20), 5264-5272.
Gonell, S.; Massey, M.; Moseley, I.; Schauer, C.; Muckerman, J.; Miller, A. J. M., The Trans Effect in Electrocatalytic CO2 Reduction: Mechanistic Studies of Asymmetric Ruthenium Pyridyl-Carbene Catalysts. J. Am. Chem. Soc. 2019, (141).
Griswold, J. A.; Johnson, J. S., Stereoconvergent Conjugate Addition of Arylboronic Acids to α-Angelica Lactone Derivatives: Synthesis of Stereochemically Complex γ-Butyrolactones. ACS Catalysis 2019, 9 (12), 11614-11618.
Holmberg-Douglas, N.; Nicewicz, D. A., Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution. Organic Letters 2019, 21 (17), 7114-7118.
Lennox, J. C.; Danilov, E. O.; Dempsey, J. L., Delayed photoacidity produced through the triplet-triplet annihilation of a neutral pyranine derivative. Phys Chem Chem Phys 2019, 21 (29), 16353-16358.
McLaughlin, M. F.; Massolo, E.; Cope, T. A.; Johnson, J. S., Phenolic Oxidation Using H2O2 via in Situ Generated para-Quinone Methides for the Preparation of para-Spiroepoxydienones. Organic Letters 2019, 21 (16), 6504-6507.
McLaughlin, M. F.; Massolo, E.; Liu, S. B.; Johnson, J. S., Enantioselective Phenolic alpha-Oxidation Using H2O2 via an Unusual Double Dearomatization Mechanism. Journal of the American Chemical Society 2019, 141 (6), 2645-2651.
Parsley, N. C.; Sadecki, P. W.; J., H. C.; Hicks, L. M., Viola “inconspicua” no more: an analysis of antibacterial cyclotides. J. Nat. Prod. 2019, 9 (82), 2537-2543.
Piszkiewicz, S.; Gunn, K.; Warmuth, O.; Propst, A.; Mehta, A.; Nguyen, K.; Kuhlman, E.; Guseman, A.; Stadmiller, S.; Boothby, T.; Neher, S.; Pielak, G., Protecting activity of desiccated enzymes. Protein Science 2019.
Ramesh, R.; Bovino, M.; Zeng, Y.; Aube, J., Synthesis of the Nonribosomal Peptide Phevalin and Analogs. J Org Chem 2019, 84 (6), 3647-3651.
Teator, A.; Leibfarth, F., Catalyst-controlled stereoselective cationic polymerization of vinyl ethers. Science 2019, 363 (6434), 1439-1443.
Wang, M.; Vannam, R.; Lambert, W.; Xie, Y.; Wang, H.; Giglio, B.; Ma, X.; Wu, Z.; Fox, J.; Li, Z., Hydrophilic 18F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging. Chemical Communications 2019, 55 (17), 2485-2488.
Wells, C.; Couñag, R. M.; Limas, J. C.; Almeida, T. L.; Cook, J. G.; Drewry, D. H.; Elkins, J. M.; Gileadi, O.; Kapadia, N. R.; Lorente-Macias, A.; Pickett, J. E.; Riemen, A.; Ruela-de-Sousa, R. R.; Willson, T. M.; Zhang, C.; Zuercher, W. J.; Zutshi, R.; Axtman, A. D., SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. ACS Publications 2019.
Wierschen, A. L.; Romano, N.; Lee, S. J.; Gagne, M. R., Silylpalladium Cations Enable the Oxidative Addition of C(sp(3))-O Bonds. Journal of the American Chemical Society 2019, 141 (40), 16024-16032.
2018
Asquith, C.; East, M.; Laitinen, T.; Tizzard, G.; Drewry, D.; Johnson, G.; Willson, T., Re-defining the oxindole chemotype to identify narrow spectrum inhibitors of the dark kinases TLK2 and PKMYT1. Abstr Pap Am Chem S 2018, 256.
Asquith, C.; Godoi, P.; Counago, R.; Laitinen, T.; Scott, J.; Langendorf, C.; Oakhill, J.; Drewry, D.; Zuercher, W.; Koutentis, P.; Willson, T.; Kalogirou, A., 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules 2018, 23 (5).
Asquith, C.; Laitinen, T.; Bennett, J.; Godoi, P.; Elkins, J.; Johnson, G.; Willson, T.; Zuercher, W., Selective inhibition of Cyclin G Associated Kinase (GAK) through manipulation of a water network. 8th RSC/SCI symposium on kinase inhibitor design, Cambridge, UK, 2018.
Bangle, R.; Sampaio, R.; Troian-Gautier, L.; Meyer, G., Surface Grafting of Ru(II) Diazonium-Based Sensitizers on Metal Oxides Enhances Alkaline Stability for Solar Energy Conversion. ACS Appl Mater Interfaces 2018, 10 (3), 3121-3132.
Brady, M.; Troian-Gautier, L.; Sampaio, R.; Motley, T.; Meyer, G., Optimization of Photocatalyst Excited- and Ground-State Reduction Potentials for Dye-Sensitized HBr Splitting. ACS Appl Mater Interfaces 2018, 10 (37), 31312-31323.
Carabajal, M.; Lobertti, C.; Asquith, C.; Zuercher, W.; Rasia, R.; García, V. E., Screening and characterization of inhibitor compounds of the Salmonella enterica PhoP/PhoQ regulatory system. SAMIGE Argentinian Microbiology Society Conference, Buenos Aires, Argentina, 2018.
Carestia, A.; Ravelli, D.; Alexanian, E., Reagent-dictated site selectivity in intermolecular aliphatic C-H functionalizations using nitrogen-centered radicals. Chem Sci 2018, 9 (24), 5360-5365.
Charaschanya, M.; Aube, J., Reagent-controlled regiodivergent ring expansions of steroids. Nature Communications 2018, 9 (1), 934.
Cooper, J.; Li, K.; Aube, J.; Coppage, D.; Konopelski, J., Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A. Organic Letters 2018, 20 (14), 4314-4317.
Downey, C.; Glist, H.; Takashima, A.; Bottum, S.; Dixon, G., Chalcone and cinnamate synthesis via one-pot enol silane formation-Mukaiyama aldol reactions of ketones and acetate esters. Tetrahedron Letters 2018, 59 (32), 3080-3083.
Fulton, J.; Horwitz, M.; Bruske, E.; Johnson, J., Asymmetric Organocatalytic Sulfa-Michael Addition to Enone Diesters. J Org Chem 2018, 83 (6), 3385-3391.
Gregor, L.; Grajeda, J.; White, P.; Vetterb, A.; Miller, A., Salt-promoted catalytic methanol carbonylation using iridium pincer-crown ether complexes. Catalysis Science & Technology 2018, 8 (12), 3133-3143.
Jin, H.; Yang, L.; Ahonen, M.; Schoenfisch, M., Nitric Oxide-Releasing Cyclodextrins. J. Am. Chem. Soc. 2018, 140 (43), 14178-14184.
Kirkpatrick, C.; Parsley, N.; Bartges, T.; Wing , C.; Kommineni, S.; Kristich, C.; Salzman, N.; Patrie, S.; Hicks, L., Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. Microbial Biotechnology 2018, 11 (5), 943-951.
Li, K.; Vorkas, C.; Chaudhry, A.; Bell, D.; Willis, R.; Rudensky, A.; Altman, J.; Glickman, M.; Aube, J., Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). PLoS One 2018, 13 (2).
Lowe, J.; Seo, Y.; Gagne, M., Boron-Catalyzed Site-Selective Reduction of Carbohydrate Derivatives with Catecholborane. ACS Catalysis 2018, 8 (9), 8192-8198.
Margrey, K.; Czaplyski, W.; Nicewicz, D.; Alexanian, E., A General Strategy for Aliphatic C-H Functionalization Enabled by Organic Photoredox Catalysis. J. Am. Chem. Soc. 2018, 140 (12), 4213-4217.
McManus, J.; Onuska, N.; Nicewicz, D., Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis. J. Am. Chem. Soc. 2018, 140 (29), 9056-9060.
Na, C.; Alexanian, E., A General Approach to Site-Specific, Intramolecular C–H Functionalization Using Dithiocarbamates. Angew Chem Int Ed Engl. 2018, 57 (40), 13106-13109.
Peruzzi, M.; Mei, Q.; Lee, S.; Gagne, M., Chemoselective amide reductions by heteroleptic fluoroaryl boron Lewis acids. Chemical Communications 2018, 54 (46), 5855-5858.
Raber, M.; Brady, M.; Troian-Gautier, L.; Dickenson, J.; Marquard, S.; Hyde, J.; Lopez, S.; Meyer, G.; Meyer, T.; Harrison, D., Fundamental Factors Impacting the Stability of Phosphonate-Derivatized Ruthenium Polypyridyl Sensitizers Adsorbed on Metal Oxide Surfaces. ACS Appl. Mater Interfaces 2018, 10 (26), 22821-22833.
S, R.; HF, M.; KM, K.; J, A., Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols. European Journal of Organic Chemistry 2018, 2018 (3), 306-315.
Troian-Gautier, L.; DiMarco, B.; Sampaio, R.; Marquard, S.; Meyer, G., Evidence that ∆S‡ Controls Interfacial Electron Transfer Dynamics from Anatase TiO2 to Molecular Acceptors. J. Am. Chem. Soc. 2018, 140 (8), 3019-3029.
Turlington, M.; Troian-Gautier, L.; Sampaio, R.; Beauvilliers, E.; Meyer, G., Ligand Control of Supramolecular Chloride Photorelease. Inorganic Chemistry 2018, 57 (9), 5624-5631.
Wang, D.; Marquard, S.; Troian-Gautier, L.; Sheridan, M.; Sherman, B.; Wang, Y.; Eberhart, M.; Farnum, B.; Dares, C.; Meyer, T., Interfacial Deposition of Ru(II) Bipyridine-Dicarboxylate Complexes by Ligand Substitution for Applications in Water Oxidation Catalysis. J. Am. Chem. Soc. 2018, 140 (2), 719-726.
Wang, M.; McNitt, C.; Wang, H.; Ma, X.; Scarry, S.; Wu, Z.; Popik, V.; Li, Z., The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide–alkyne reaction: reaction speed versus hydrophilicity. Chemical Communications 2018, 54 (56), 7810-7813.
Wehlin, S.; Troian-Gautier, L.; Sampaio, R.; Marcelis, L.; Meyer, G., Ter-Ionic Complex that Forms a Bond Upon Visible Light Absorption. J. Am. Chem. Soc. 2018, 140 (25), 7799-7802.
2017
Camp, A.; Kita, M.; Grajeda, J.; White, P.; Dickie, D.; Miller, A., Mapping the Binding Modes of Hemilabile Pincer–Crown Ether Ligands in Solution Using Diamagnetic Anisotropic Effects on NMR Chemical Shift. Inorganic Chemistry 2017, 56 (18), 11141-11150.
Guseman, A.; Pielak, G., Cosolute and Crowding Effects on a Side-By-Side Protein Dimer. Biochemistry 2017, 56 (7), 971-976.
KA, M.; A, L.; D, N., Direct C-H Arylation of Primary Amines via Organic Photoredox Catalysis. Angew Chem Int Ed Engl. 2017, 56 (49), 15644-15648.
Motley, T.; Troian-Gautier, L.; Brennaman, M.; Meyer, G., Excited-State Decay Pathways of Tris(bidentate) Cyclometalated Ruthenium(II) Compounds. Inorganic Chemistry 2017, 56 (21), 13579-13592.
Peruzzi, M.; Lee, S.; Gagne, M., Gold(I) Catalyzed Dearomative Claisen Rearrangement of Allyl, Allenyl Methyl, and Propargyl Aryl Ethers. Organic Letters 2017, 19 (22), 6256–6259.
Pitman, C.; Miller, A., Photochemical Production of Ethane from an Iridium Methyl Complex. Organometallics 2017, 36 (10), 1906-1914.
Sargent, B.; Alexanian, E., Cobalt-Catalyzed Carbonylative Cross-Coupling of Alkyl Tosylates and Dienes: Stereospecific Synthesis of Dienones at Low Pressure. J. Am. Chem. Soc. 2017, 139 (36), 12438-12440.
Stadmiller, S.; Gorensek-Benitez, A.; Guseman, A.; Pielak, G., Osmotic Shock Induced Protein Destabilization in Living Cells and Its Reversal by Glycine Betaine. Journal of Molecular Biology 2017, 429 (8), 1155-1161.
Tay, N.; Nicewicz, D., Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis. J. Am. Chem. Soc. 2017, 139 (45), 16100-16104.