Asquith, C. R. M.;  Laitinen, T.;  Bennett, J. M.;  Wells, C. I.;  Elkins, J. M.;  Zuercher, W. J.;  Tizzard, G. J.; Poso, A., Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem 2020, 15 (1), 26-49.

Asquith, C. R. M.; Laitinen, T.;  Wells, C. I.;  Tizzard, G. J.; Zuercher, W. J., New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K). Molecules 2020, 25 (7).

Bruch, Q. J.; Miller, A., A bis(arylphosphinito)amide pincer ligand that binds nickel forming six-membered metallacycles. Polyhedron 2020, 179, 114380.

Kessler, M. L.; Dempsey, J. L., Mapping the Topology of PbS Nanocrystals through Displacement Isotherms of Surface-Bound Metal Oleate Complexes. Chemistry of Materials 2020, 32 (6), 2561-2571.

Smith, K. L.; Padgett, C. L.;  Mackay, W. D.; Johnson, J. S., Catalytic, Asymmetric Dearomative Synthesis of Complex Cyclohexanes via a Highly Regio- and Stereoselective Arene Cyclopropanation Using α-Cyanodiazoacetates. Journal of the American Chemical Society 2020, 142 (14), 6449-6455.

Zavesky, B. P.; De Jesús Cruz, P.; Johnson, J. S., Progress toward a Convergent, Asymmetric Synthesis of Jervine. Organic Letters 2020.


Asquith, C.;  Berger, B.;  Wan, J.;  Bennett, J.;  East, M.;  Elkins, J.;  Fedorov, O.;  Godoi, P.;  Hunter, D.;  Knapp, S.;  Mueller, S.;  Wells, C.;  H. Earp, S.;  Willson, T.; Zuercher, W., SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem 2019, 62 (5), 2830-2836.

Asquith, C.; Bieberich, A.;  Maffuid, K.;  Fatig, R.;  Tizzard, G.;  Laitinen, T.;  East, M.;  Torrice, C.;  Drewry, D.;  Johnson, G.;  Crona, D.;  Calvin, B.;  Morris, D.; Zuercher, W., Optimization of structural features of the 4-anilinoquin(az)oline scaffold for chordoma utilizing an innovative toxicology profiling assay panel. Abstr Pap Am Chem S 2019, 257.

Asquith, C.; Maffuid, K.;  Laitinen, T.;  Torrice, C.;  Tizzard, G.;  Alamillo-Ferrer, C.;  Koshlap, K.;  Crona, D.; Zuercher, W., Design and evaluation of novel 4-anilinoquinolines and quinazolines as EGFR inhibitors in lung cancer and chordoma. 2019.

Asquith, C. R. M.; Bennett, J. M.;  Su, L. Y.;  Laitinen, T.;  Elkins, J. M.;  Pickett, J. E.;  Wells, C. I.;  Li, Z. B.;  Willson, T. M.; Zuercher, W. J., Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK). Molecules 2019, 24 (22).

Asquith, C. R. M.; Fleck, N.;  Torrice, C. D.;  Crona, D. J.;  Grundner, C.; Zuercher, W. J., Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines. Bioorg Med Chem Lett 2019, 29 (18), 2695-2699.

Asquith, C. R. M.; Laitinen, T.;  Bennett, J. M.;  Wells, C. I.;  Elkins, J. M.;  Zuercher, W. J.;  Tizzard, G. J.; Poso, A., Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships. ChemMedChem 2019.

Asquith, C. R. M.; Maffuid, K. A.;  Laitinen, T.;  Torrice, C. D.;  Tizzard, G. J.;  Crona, D. J.; Zuercher, W. J., Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma. ChemMedChem 2019, 14 (19), 1693-1700.

Asquith, C. R. M.; Naegeli, K. M.;  East, M. P.;  Laitinen, T.;  Havener, T. M.;  Wells, C. I.;  Johnson, G. L.;  Drewry, D. H.;  Zuercher, W. J.; Morris, D. C., Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma. Journal of Medicinal Chemistry 2019, 62 (9), 4772-4778.

Asquith, C. R. M.; Tizzard, G. J., 6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine. Molbank 2019, 2019, M1087.

Asquith, C. R. M.; Treiber, D. K.; Zuercher, W. J., Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK) Bioorg. Med. Chem. Lett. 2019, 29, 1727-1731.

Ballinger, E.; Mosior, J.;  Hartman, T.;  Burns-Huang, K.;  Gold, B.;  Morris, R.;  Goullieux, L.;  Blanc, I.;  Vaubourgeix, J.;  Lagrange, S.;  Fraisse, L.;  Sans, S.;  Couturier, C.;  Bacqué, E.;  Rhee, K.;  Scarry, S.;  Aube, J.;  Yang, G.;  Ouerfelli, O.;  Schnappinger, D.;  Loerger, T.;  Engelhart, C.;  McConnell, J.;  McAulay, K.;  Fay, A.;  Roubert, C.;  Sacchettini, J.; Nathan, C., Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science 2019, 363 (6426).

Bruch, Q. J.; Connor, G. P.;  Chen, C.;  Holland, P. L.;  Mayer, J. M.;  Hasanayn, F.; Miller, A., Dinitrogen Reduction to Ammonium at Rhenium Utilizing Light and Proton-Coupled Electron Transfer. Journal of the American Chemical Society 2019, 141 (51), 20198-20208.

Carabajal, M. A.; Asquith, C. R. M.;  Laitinen, T.;  Tizzard, G. J.;  Yim, L.;  Rial, A.;  Chabalgoity, J. A.;  Zuercher, W. J.; Garcia Vescovi, E., Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System. Antimicrob Agents Chemother 2019, 64 (1).

Cesta, D.; Karakaya, S.;  Saito, K.;  Javidnia, P.;  Roberts, J.;  Ling, Y.;  Gold, B.;  Quezada, L.;  Zhang, D.;  Abramyan, T.;  Kireev, D.;  Aube, J.; Scarry, S., Synthesis and Antibacterial Evaluation of Cephalosporin Isosteres. Asian Journal of Organic Chemistry 2019.

Ervin, S. M.; Hanley, R. P.;  Lim, L.;  Walton, W. G.;  Pearce, K. H.;  Bhatt, A. P.;  James, L. I.; Redinbo, M. R., Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial b-Glucuronidases. ACS Chemical Biology 2019.

Goines, S.; Dick, J. E., Electrochemical Characterization of Nicotinamide Riboside. ChemElectroChem 2019, 6 (20), 5264-5272.

Gonell, S.; Massey, M.;  Moseley, I.;  Schauer, C.;  Muckerman, J.; Miller, A. J. M., The Trans Effect in Electrocatalytic CO2 Reduction: Mechanistic Studies of Asymmetric Ruthenium Pyridyl-Carbene Catalysts. J. Am. Chem. Soc. 2019,  (141).

Griswold, J. A.; Johnson, J. S., Stereoconvergent Conjugate Addition of Arylboronic Acids to α-Angelica Lactone Derivatives: Synthesis of Stereochemically Complex γ-Butyrolactones. ACS Catalysis 2019, 9 (12), 11614-11618.

Holmberg-Douglas, N.; Nicewicz, D. A., Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution. Organic Letters 2019, 21 (17), 7114-7118.

Lennox, J. C.; Danilov, E. O.; Dempsey, J. L., Delayed photoacidity produced through the triplet-triplet annihilation of a neutral pyranine derivative. Phys Chem Chem Phys 2019, 21 (29), 16353-16358.

McLaughlin, M. F.; Massolo, E.;  Cope, T. A.; Johnson, J. S., Phenolic Oxidation Using H2O2 via in Situ Generated para-Quinone Methides for the Preparation of para-Spiroepoxydienones. Organic Letters 2019, 21 (16), 6504-6507.

McLaughlin, M. F.; Massolo, E.;  Liu, S. B.; Johnson, J. S., Enantioselective Phenolic alpha-Oxidation Using H2O2 via an Unusual Double Dearomatization Mechanism. Journal of the American Chemical Society 2019, 141 (6), 2645-2651.

Parsley, N. C.; Sadecki, P. W.;  J., H. C.; Hicks, L. M., Viola “inconspicua” no more: an analysis of antibacterial cyclotides. J. Nat. Prod. 2019, 9 (82), 2537-2543.

Piszkiewicz, S.; Gunn, K.;  Warmuth, O.;  Propst, A.;  Mehta, A.;  Nguyen, K.;  Kuhlman, E.;  Guseman, A.;  Stadmiller, S.;  Boothby, T.;  Neher, S.; Pielak, G., Protecting activity of desiccated enzymes. Protein Science 2019.

Ramesh, R.; Bovino, M.;  Zeng, Y.; Aube, J., Synthesis of the Nonribosomal Peptide Phevalin and Analogs. J Org Chem 2019, 84 (6), 3647-3651.

Teator, A.; Leibfarth, F., Catalyst-controlled stereoselective cationic polymerization of vinyl ethers. Science 2019, 363 (6434), 1439-1443.

Wang, M.; Vannam, R.;  Lambert, W.;  Xie, Y.;  Wang, H.;  Giglio, B.;  Ma, X.;  Wu, Z.;  Fox, J.; Li, Z., Hydrophilic 18F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging. Chemical Communications 2019, 55 (17), 2485-2488.

Wells, C.; Couñag, R. M.;  Limas, J. C.;  Almeida, T. L.;  Cook, J. G.;  Drewry, D. H.;  Elkins, J. M.;  Gileadi, O.;  Kapadia, N. R.;  Lorente-Macias, A.;  Pickett, J. E.;  Riemen, A.;  Ruela-de-Sousa, R. R.;  Willson, T. M.;  Zhang, C.;  Zuercher, W. J.;  Zutshi, R.; Axtman, A. D., SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. ACS Publications 2019.

Wierschen, A. L.; Romano, N.;  Lee, S. J.; Gagne, M. R., Silylpalladium Cations Enable the Oxidative Addition of C(sp(3))-O Bonds. Journal of the American Chemical Society 2019, 141 (40), 16024-16032.


Asquith, C.; East, M.;  Laitinen, T.;  Tizzard, G.;  Drewry, D.;  Johnson, G.; Willson, T., Re-defining the oxindole chemotype to identify narrow spectrum inhibitors of the dark kinases TLK2 and PKMYT1. Abstr Pap Am Chem S 2018, 256.

Asquith, C.; Godoi, P.;  Counago, R.;  Laitinen, T.;  Scott, J.;  Langendorf, C.;  Oakhill, J.;  Drewry, D.;  Zuercher, W.;  Koutentis, P.;  Willson, T.; Kalogirou, A., 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules 2018, 23 (5).

Asquith, C.; Laitinen, T.;  Bennett, J.;  Godoi, P.;  Elkins, J.;  Johnson, G.;  Willson, T.; Zuercher, W., Selective inhibition of Cyclin G Associated Kinase (GAK) through manipulation of a water network. 8th RSC/SCI symposium on kinase inhibitor design, Cambridge, UK, 2018.

Bangle, R.; Sampaio, R.;  Troian-Gautier, L.; Meyer, G., Surface Grafting of Ru(II) Diazonium-Based Sensitizers on Metal Oxides Enhances Alkaline Stability for Solar Energy Conversion. ACS Appl Mater Interfaces 2018, 10 (3), 3121-3132.

Brady, M.; Troian-Gautier, L.;  Sampaio, R.;  Motley, T.; Meyer, G., Optimization of Photocatalyst Excited- and Ground-State Reduction Potentials for Dye-Sensitized HBr Splitting. ACS Appl Mater Interfaces 2018, 10 (37), 31312-31323.

Carabajal, M.; Lobertti, C.;  Asquith, C.;  Zuercher, W.;  Rasia, R.; García, V. E., Screening and characterization of inhibitor compounds of the Salmonella enterica PhoP/PhoQ regulatory system. SAMIGE Argentinian Microbiology Society Conference, Buenos Aires, Argentina, 2018.

Carestia, A.; Ravelli, D.; Alexanian, E., Reagent-dictated site selectivity in intermolecular aliphatic C-H functionalizations using nitrogen-centered radicals. Chem Sci 2018, 9 (24), 5360-5365.

Charaschanya, M.; Aube, J., Reagent-controlled regiodivergent ring expansions of steroids. Nature Communications 2018, 9 (1), 934.

Cooper, J.; Li, K.;  Aube, J.;  Coppage, D.; Konopelski, J., Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A. Organic Letters 2018, 20 (14), 4314-4317.

Downey, C.; Glist, H.;  Takashima, A.;  Bottum, S.; Dixon, G., Chalcone and cinnamate synthesis via one-pot enol silane formation-Mukaiyama aldol reactions of ketones and acetate esters. Tetrahedron Letters 2018, 59 (32), 3080-3083.

Fulton, J.; Horwitz, M.;  Bruske, E.; Johnson, J., Asymmetric Organocatalytic Sulfa-Michael Addition to Enone Diesters. J Org Chem 2018, 83 (6), 3385-3391.

Gregor, L.; Grajeda, J.;  White, P.;  Vetterb, A.; Miller, A., Salt-promoted catalytic methanol carbonylation using iridium pincer-crown ether complexes. Catalysis Science & Technology 2018, 8 (12), 3133-3143.

Jin, H.; Yang, L.;  Ahonen, M.; Schoenfisch, M., Nitric Oxide-Releasing Cyclodextrins. J. Am. Chem. Soc. 2018, 140 (43), 14178-14184.

Kirkpatrick, C.; Parsley, N.;  Bartges, T.;  Wing , C.;  Kommineni, S.;  Kristich, C.;  Salzman, N.;  Patrie, S.; Hicks, L., Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. Microbial Biotechnology 2018, 11 (5), 943-951.

Li, K.; Vorkas, C.;  Chaudhry, A.;  Bell, D.;  Willis, R.;  Rudensky, A.;  Altman, J.;  Glickman, M.; Aube, J., Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). PLoS One 2018, 13 (2).

Lowe, J.; Seo, Y.; Gagne, M., Boron-Catalyzed Site-Selective Reduction of Carbohydrate Derivatives with Catecholborane. ACS Catalysis 2018, 8 (9), 8192-8198.

Margrey, K.; Czaplyski, W.;  Nicewicz, D.; Alexanian, E., A General Strategy for Aliphatic C-H Functionalization Enabled by Organic Photoredox Catalysis. J. Am. Chem. Soc. 2018, 140 (12), 4213-4217.

McManus, J.; Onuska, N.; Nicewicz, D., Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis. J. Am. Chem. Soc. 2018, 140 (29), 9056-9060.

Na, C.; Alexanian, E., A General Approach to Site-Specific, Intramolecular C–H Functionalization Using Dithiocarbamates. Angew Chem Int Ed Engl. 2018, 57 (40), 13106-13109.

Peruzzi, M.; Mei, Q.;  Lee, S.; Gagne, M., Chemoselective amide reductions by heteroleptic fluoroaryl boron Lewis acids. Chemical Communications 2018, 54 (46), 5855-5858.

Raber, M.; Brady, M.;  Troian-Gautier, L.;  Dickenson, J.;  Marquard, S.;  Hyde, J.;  Lopez, S.;  Meyer, G.;  Meyer, T.; Harrison, D., Fundamental Factors Impacting the Stability of Phosphonate-Derivatized Ruthenium Polypyridyl Sensitizers Adsorbed on Metal Oxide Surfaces. ACS Appl. Mater Interfaces 2018, 10 (26), 22821-22833.

S, R.; HF, M.;  KM, K.; J, A., Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols. European Journal of Organic Chemistry 2018, 2018 (3), 306-315.

Troian-Gautier, L.; DiMarco, B.;  Sampaio, R.;  Marquard, S.; Meyer, G., Evidence that ∆S‡ Controls Interfacial Electron Transfer Dynamics from Anatase TiO2 to Molecular Acceptors. J. Am. Chem. Soc. 2018, 140 (8), 3019-3029.

Turlington, M.; Troian-Gautier, L.;  Sampaio, R.;  Beauvilliers, E.; Meyer, G., Ligand Control of Supramolecular Chloride Photorelease. Inorganic Chemistry 2018, 57 (9), 5624-5631.

Wang, D.; Marquard, S.;  Troian-Gautier, L.;  Sheridan, M.;  Sherman, B.;  Wang, Y.;  Eberhart, M.;  Farnum, B.;  Dares, C.; Meyer, T., Interfacial Deposition of Ru(II) Bipyridine-Dicarboxylate Complexes by Ligand Substitution for Applications in Water Oxidation Catalysis. J. Am. Chem. Soc. 2018, 140 (2), 719-726.

Wang, M.; McNitt, C.;  Wang, H.;  Ma, X.;  Scarry, S.;  Wu, Z.;  Popik, V.; Li, Z., The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide–alkyne reaction: reaction speed versus hydrophilicity. Chemical Communications 2018, 54 (56), 7810-7813.

Wehlin, S.; Troian-Gautier, L.;  Sampaio, R.;  Marcelis, L.; Meyer, G., Ter-Ionic Complex that Forms a Bond Upon Visible Light Absorption. J. Am. Chem. Soc. 2018, 140 (25), 7799-7802.


Camp, A.; Kita, M.;  Grajeda, J.;  White, P.;  Dickie, D.; Miller, A., Mapping the Binding Modes of Hemilabile Pincer–Crown Ether Ligands in Solution Using Diamagnetic Anisotropic Effects on NMR Chemical Shift. Inorganic Chemistry 2017, 56 (18), 11141-11150.

Guseman, A.; Pielak, G., Cosolute and Crowding Effects on a Side-By-Side Protein Dimer. Biochemistry 2017, 56 (7), 971-976.

KA, M.; A, L.; D, N., Direct C-H Arylation of Primary Amines via Organic Photoredox Catalysis. Angew Chem Int Ed Engl. 2017, 56 (49), 15644-15648.

Motley, T.; Troian-Gautier, L.;  Brennaman, M.; Meyer, G., Excited-State Decay Pathways of Tris(bidentate) Cyclometalated Ruthenium(II) Compounds. Inorganic Chemistry 2017, 56 (21), 13579-13592.

Peruzzi, M.; Lee, S.; Gagne, M., Gold(I) Catalyzed Dearomative Claisen Rearrangement of Allyl, Allenyl Methyl, and Propargyl Aryl Ethers. Organic Letters 2017, 19 (22), 6256–6259.

Pitman, C.; Miller, A., Photochemical Production of Ethane from an Iridium Methyl Complex. Organometallics 2017, 36 (10), 1906-1914.

Sargent, B.; Alexanian, E., Cobalt-Catalyzed Carbonylative Cross-Coupling of Alkyl Tosylates and Dienes: Stereospecific Synthesis of Dienones at Low Pressure. J. Am. Chem. Soc. 2017, 139 (36), 12438-12440.

Stadmiller, S.; Gorensek-Benitez, A.;  Guseman, A.; Pielak, G., Osmotic Shock Induced Protein Destabilization in Living Cells and Its Reversal by Glycine Betaine. Journal of Molecular Biology 2017, 429 (8), 1155-1161.

Tay, N.; Nicewicz, D., Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis. J. Am. Chem. Soc. 2017, 139 (45), 16100-16104.